What's new

IMF 39, September 2026 - Updates to Prescribing, Safety Information

New Molecules, Combinations, Generic Equivalents, Presentations

No Longer Available (Discontinued Products)

Each new edition of IMF highlights new products i.e. new molecules and new combinations, as well as new generic equivalents, new formulations and new presentations. New information sourced from important safety updates and revisions to existing drug licenses appears in the prescribing information for individual drugs and/or Class Effects for various sections.

New Molecules, New Combinations

• Childhood Immunisation: DTP, Pertussis, Haemophilus type b, Hepatitis B Vaccine (Vaxelis Vaccine)
• Cardiomyopathy: Mavacamten (▼CAMZYOS 2.5mg, 5mg, 10mg, 15mg)
• COVID-19 Immunisation: mRNA XFG (▼Comirnaty XFG Vaccine 30mcg, 10mcg)
• Dementia: Lecanemab (▼LEQEMBI Parenteral 100mg/mL)
• Friedreich's Ataxia: Omaveloxolone (▼Skyclarys 50mg)
• Infestations: Ivermectin (systemic) (Iverscab 3mg)
• Inflammatory Skin Conditions: Spesolimab (▼Spevigo Parenteral 450mg)
• Inflammatory Skin Conditions: Lebrikizumab (▼Ebglyss 250mg PFP, PFS)
• Oncology: Lorlatinib (Lorviqua 25mg, 100mg)
• Oncology: Toripalimab (▼LOQTORZI Parenteral 240mg)
• Oncology: Selumetinib (▼Koselugo 10mg, 20mg)
• Opioid-Induced Constipation: Naldemedine (Rizmoic Tablets 200mcg)

In addition to new medicines, a number of existing medicines have been updated with new formulations, new strengths, or new presentations. The are 8 new presentations and details for each of these changes are included in the relevant entries.

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No Longer Available

Discontinued before publication of IMF 39, September 2026:

• Actonel 5mg
• Actonel Combi, Actonel Plus
• Benazepril 10mg
• Bisolvon Oral Solution 4mg/5mL
• Bisopine (range)
• Buplex Rx (600mg strength only)
• Calvidin 600mg/400 IU Chewable Tablet
• Ciprofloxacin Teva 250mg (all pack sizes)
• Clarithromycin Krka (range)
• Clomid 50mg (30-pack only)
• Co-Danthromer 25mg/200mg Suspension
• Cosartal Plus (range)
• Co-Tipol Maximum Suppositories 1000mg/60mg
• Cymbalta 30mg, 60mg
• Desloratadine (Accord) 5mg
• Epanutin 300mg (500-pack only)
• Esmeron Parenteral 10mg/mL
• Ezetimibe TEVA 10mg
• Febuxostat Krka (range)
• Imnovid (range)
• Irbesartan Rowa (range)
• Ireven 75mg, 150mg
• Isentress Chewable (25mg strength only)
• Ixprim 37.5mg/325mg (effervescent formulation only)
• Lamisil Tablets 250mg
• Latacris Eye Drops 50mcg/mL
• Lestace (range)
• Lisopress (2.5mg strength only)
• Losartan Rowa (range)
• Maxilief 8mg/500mg/30mg
• Micolette Micro-Enema
• Mydrilate 0.5%, 1% Eye Drops
• Pradaxa (granule formulation only)
• Prasugrel Krka 10mg
• Propafenone (Accord) 150mg, 300mg
• Pulmicort Turbohaler (400mcg strength only)
• Revlimid (20mg strength only)
• Risedronate Accord Once Weekly 35mg
• Risedronate Pinewood Once A Week 35mg

Discontinued before publication of IMF 38, March 2026:

• Atrovent CFC-Free Inhaler (pMDI)
• Champix (entire range)
• Exorex 5% Lotion
• Flucloxacillin (Athlone) 250mg (500-pack only)
• Humalog Mix 25, 50 (cartridges only)
• Insulatard Penfill 100 IU (cartridge 3mL only).
• Kanjinti Parenteral 150mg
• Lasix Parenteral 20mg/2mL
• Levothyroxine (ADVANZ) Oral Solution
• Luveris Parenteral 75 IU
• Menopur Parenteral (75 IU only)
• Mimpara Tablets, Granules
• Oramox 250mg
• Praxilene 100mg
• Sandimmun Capsules (all strengths), Oral Solution
• Singulair (Paediatric 4mg Granules only)
• Uniphyllin Continus tablets (entire range)
• Victoza Parenteral (entire range)
• Zejula 100mg

Discontinued before publication of IMF 37, September 2025:

• Adcortyl Parenteral 10mg/mL
• Alendronic Acid Accord Once Weekly
• Amoclav (250/125mg strength only)
• Aprovel (range)
• Azacitidine Rowex Parenteral 25mg/mL
• Betagan UDV 5mg/mL Eye Drops
• Betnovate RD Cream
• Bortezomib Mylan Parenteral 3.5mg
• Buscopan Rx (still available as OTC)
• Combigan Eye Drops
• COSOPT Eye Drops (only preservative-free UDV)
• Creon (40000 strength only)
• Darunavir Rowex 800mg
• Diabrezide 80mg
• Diazepam (Accord) 2mg, 10mg
• Diclac Parenteral 25mg/mL
• Differin 0.1% (Cream formulation only)
• Diprobase Cream, Ointment
• Donecept 5mg, 10mg
• Dorzolamide/Timolol (Accord) Eye Drops
• Eczibet Cream
• Enerzair Breezhaler
• Etrivex Shampoo 500mcg/g
• FEIBA (50 U/mL strength only)
• FML 0.1% Eye Drops Suspension
• Fucidin 250mg tablets
• Imigran Ftab 100mg (2-pack only)
• Irbesartan Accord (entire range)
• Ivabradine Accord 5mg, 7.5mg
• Lamictal Dispersible Tablets (5mg-strength only)
• Lanoxin Parenteral 500mcg/2mL
• Lanzol (15mg strength only)
• Losartan Rowa (100mg strength only)
• Motilium Oral Suspension
• Nicochew Mint Gum 2mg, 4mg
• Nizoral Cream 2%
• Normacol 62% Granules
• Olmesartan (Gerard) (entire range)
• OxyContin (80mg strength only)
• Pantoflux 20mg, 40mg
• Phyllocontin Continus 225mg
• Pramipexole Accord 0.18mg
• Pred Mild 0.12% Eye Drops
• Primacine Susp 125mg, 250mg
• Raloxifene (Accord) 60mg
• Ramipril (Accord) 2.5mg, 5mg, 10mg
• Relestat Eye Drops 0.5mg/mL
• Reminyl (entire range)
• Reminyl Oral Soln
• Rolyprexa (2.5mg, 15mg strengths only)
• Saflutan Eye Drops (Multidose bottle)
• Salofalk (tablets 250mg only)
• Seroxat (10mg, 30mg strengths only)
• Spasmonal (60mg strength only)
• Stesolid Rectal Tubes (entire range)
• Stieprox 15mg/g Shampoo
• Stilnoct 5mg (14-pack only)
• Synagis Parenteral 100mg/mL
• Targin Prolonged Release (60mg/30mg strength only)
• Tavanic 500mg
• Tavanic Parenteral 5mg/mL
• Tendrotil SR 2mg, 4mg
• Tenkasi Parenteral (400mg strength replaces with 1200mg strength)
• Timoptol Eye Drops 0.25%, 0.5%
• Tradol Injection 100mg/2mL
• Tritace (1.25mg strength only)
• Uniphyllin Continus tablets (200mg, 300mg only)
• Viscolex Syrup 250mg/5mL
• VisuXL Eye Drops (rest of range remains)
• VisuXL Gel (5mL presentation only)

Discontinued before publication of IMF 36, March 2025:

• Apixaban (Accord) (range)
• Aspirin (Clonmel) 75mg
• Belkyra Parenteral 10mg/mL
• Brinzolamide (Accord) Eye Drops
• Carbimazole (Essential) Tablets (range)
• Centrax 10mg
• Cinacalcet Rowex (range)
• Comirnaty Original COVID-19 Vaccine
• Comirnaty Original/Omicron BA.1 COVID-19 Vaccine
• Comirnaty Original/Omicron BA.4-5 COVID-19 Vaccine
• Eligard Parenteral (7.5mg strength only)
• FEIBA Parenteral (25 IU/mL strength only)
• Femara 2.5mg
• Fingolimod Krka 0.5mg
• Flamazine Cream
• Imatinib (Pinewood) (entire range)
• JCOVDEN COVID-19 Vaccine
• Latanoprost (Accord) Eye Drops 50mcg/mL
• Levemir Innolet 100 units/mL
• Losamel 20mg
• Nemdatine 10mg
• Nuvaxovid COVID-19 Vaccine
• OCALIVA 5mg, 10mg
• Oruvail 200mg
• Repaglinide (Accord) (range)
• Simvastatin (Accord) (range)
• Spikevax Original/Omicron BA.4-5 COVID-19 Vaccine
• Spikevax Original COVID-19 Vaccine
• Spikevax Original/Omicron BA.1 COVID-19 Vaccine
• Terbasil 250mg

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Discontinued before publication of IMF 35, September 2024:

• Agomelatine Accord 25mg
• Bonefurbit 150mg
• Celecoxib (Key) 100mg, 200mg
• Diflazole (range)
• Entyvio Parenteral 108mg (PFS only)
• Fluenz Tetra Nasal Vaccine (flu vaccine)
• Fungasil 1% Cream
• Giotrif (50mg strength only)
• Hyrimoz Parenteral 40mg
• Irprestan (range)
• Isomonit Retard 60mg
• Komboglyze (entire range)
• Memantine LEK 10mg
• MST Continus (60mg strength only)
• Onglyza (2.5mg strength only)
• Oxis Turbohaler (range)
• Prosentio 100mg
• Prozac 20mg (parallel import)
• Pulmicort Turbohaler 100mcg (200-dose)
• Purinol (range)
• Temodal Capsules (entire range)
• Vaxzevria COVID-19 Vaccine
• Zaltrap Parenteral 25mg/mL
• Zolpidem (Key) 5mg, 10mg
• Zostavax Vaccine

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Discontinued before publication of IMF 34, March 2024:

• Acetylcysteine Essential 600mg
• Acidex Suspension (entire range)
• Aldara 5% Sachets
• Amlodipine/Valsartan/HCTZ (Rowex) (entire range)
• Aprovel (75mg strength only)
• Azithromycin (Accord) 250mg
• Benetor (entire range)
• Benetor Plus (entire range)
• Betnovate-C Cream
• Blopress (entire range)
• Blopress Plus (entire range)
• Cinacalcet Accord (range)
• Cinacalcet Rowex (30mg strength only)
• Colifoam 10% Rectal Foam
• Dalmpam (entire range)
• Dexketoprofen Rowex 25mg
• Dorzolaminde Accord Eye Drops
• Doxacar Prolonged/R 4mg
• Efavirenz Rowex 600mg
• Emend (2-day treatment pack only)
• Ezetimibe/Simvastatin (Mylan) (entire range)
• Feldene Topical Gel
• Flagyl 1g Suppositories
• Flagyl tabs (200mg strength only)
• Foradil Aerolizer 12mcg
• Galfer FA
• Gyno-Daktarin (entire range)
• Ikorel (range)
• Kapake (entire range)
• Klariger 500mg
• Lipertance Tablets (range)
• Lipocomb Capsules (range)
• Mirvaso Gel
• Nutilis Powder (300g pack only)
• Ondansetron (Rowex) Parenteral
• Ondansetron (Rowex) Tablets (entire range)
• Pantoprazole Mylan (entire range)
• Pemetrexed Rowex 25mg/mL (all presentations)
• Pradaxa 150mg (10-pack only)
• Pravastatin (Accord) (entire range)
• Pravastatin Mylan (entire range)
• Psoriderm Cream
• Rabeprazole (Accord) (range)
• Rasagiline Mylan 1mg
• Razole 20mg
• Rivastigmine Sandoz Caps (entire range)
• Rosuva Tablets (entire range)
• Rozex Cream/Gel
• Selincro 18mg (14-pack only)
• Sevredol (50mg strength only)
• Sibelium 5mg
• Sildenafil Mylan (entire range)
• Skudexa (granule presentation only)
• Solifenacin (Myland) (10mg strength only)
• Steglatro (entire range)
• Steglujan (entire range)
• Tavanic (250mg strength only)
• Telmisartan Mylan (entire range)
• Telmisartan/Hydrochlorothiazide Rowa (80/25 strength only)
• Zinnat (125mg tablet only)
• Zofran Parenteral
• Zykadia 150mg

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Discontinued before publication of IMF 33, September 2023:

• Adempas 1mg, 2mg (84-pack only)
• Amaryl 3mg
• Angiox Parenteral 250mg
• Augmentin Parenteral 600mg, 1.2g
• Busilvex Parenteral 6mg/mL
• Canesten Pessary 200mg, Duopak
• Cantaxel Parenteral 6mg/mL
• Catasart (entire range)
• Celecoxib Rowex (entire range)
• Ciprofloxacin Mylan Parenteral 2mg/mL
• Clavamel 250/125mg, Paed Susp 125/31.25mg
• Condyline Cutaneous Soln
• DepoCyte Intrathecal
• Eloxatin Parenteral 5mg/mL
• Entyvio Parenteral 108mg (PFS presentatin only)
• Epirubicin Teva 2mg/mL
• Esomeprazole (Accord) 20mg, 40mg (capsule formulation only)
• Etoricoxib (Rowex) (120mg strength only)
• Ezetimibe/Simvastatin Rowex (entire range)
• Febuxostat (Mylan) (entire range)
• Flotros 20mg
• Fludara 10mg, Parenteral 25mg/mL
• Gabapentin (Accord) (entire range)
• Glimepiride (Accord) (entire range)
• Hepsera 10mg
• Histaclar 10mg
• Ibrance (capsules only)
• Iressa 250mg
• Lenalidomide Mylan (entire range)
• Levact Parenteral 100mg
• Mayzent 0.25mg (120-pack only)
• Meningitec Vaccine
• Mitomycin-C
• Mitoxantrone Parenteral 2mg/mL
• Myleran 2mg
• Nuasa 75mg
• NutropinAq Parenteral
• Pemetrexed Rowex Parenteral 25mg/mL
• Primolut N 5mg
• Ratiograstim Parenteral
• Risedronate Pinewood (5mg only)
• Rixathon Parenteral 100mg, 500mg
• Septrin Paed Susp (50mL pack only)
• Talmanco 20mg
• Taxotere Conc Parenteral 20mg/mL
• Tears Naturale Eye Drops
• Terazosin 2mg
• Thorens (capsules 25000 IU only)
• Tramake 50mg, 100mg

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Discontinued before publication of IMF 32, March 2023:

• Abstral Sublingual (800mcg 10-Pack only)
• Acidex Liquid (200mL-pack only)
• Actiq Lozenges (200mcg 3-pack, 1200mcg 30-pack only)
• Amoxil Parenteral 500mg
• Aripiprazole (Pinewood) Oral Soln
• Aripiprazole Sandoz (range)
• Atenetic (range)
• Betnovate Cream (100g only)
• Betnovate RD Ointment
• Brieka Caps (range)
• CoAprovel (range)
• Daktacort Cream
• Dithrocream 0.1%
• Duphalac (300mL-pack only)
• Duphalac Oral Soln 3.335g/5mL 1L
• Effentora Buccal 100mcg, 200mcg (4-pack only)
• Elantan (40mg-strength only)
• Erythroped Susp (range)
• Esbriet (capsule formulations)
• Estelle 75/30
• Eumovate (ointment only)
• Ezetimibe (Key) 10mg
• Frumil (56-pack only)
• Frumil Low Strength
• Gyno-Daktarin Vaginal Cream
• Hydrocortisyl 1% Cream
• Imuran (parenteral only)
• Indivina (range)
• Instanyl Nasal Spray
• Istolde (range)
• Lanoxin 0.25mg
• Laxose Oral Soln 3.35g/5mL
• Micardis (20mg-strength only)
• NiQuitin Mini Mint Lozenges (60-pack replaced with 100-pack)
• Omeprazole Rowa (10mg-strength only)
• Osteofos D3 Sachets
• Pinamox Oral susp (125mg/5mL-only)
• Pinemox Caps 250mg (1000-pack only)
• Pregabalin Mylan (200mg-strength only)
• Pregabalin Mylan (range)
• Rasilez HCT (range)
• Retacrit (3, 5, 6, 10 thousand IU strengths only)
• Retacrit (4000, 8000 IU strengths only)
• Seroxat Oral Susp
• Sofradex Eye/Ear Drops
• Soolantra (30g-pack only).
• Tamiflu 30mg and 45mg capsules
• Tarivid 200mg, Parenteral 2mg/mL
• Tenofovir (Accord) 245mg
• Tolura (2mg-strength only)
• Trandate 250mg (250-pack only)
• Truoxin (entire range)
• Truoxin 250mg (10-pack only)
• Ventolin Nebules (range)
• Veramil 80mg
• Vimpat 100mg, 150mg, 200mg (14-pack only)
• Vitile MR 30mg
• Xymel 50mg
• Xymel Comp 37.5/325mg
• Xyzal (oral drops only)
• Zirpine 10mg
• Zyloric (100mg-strength only)

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